Diabesity negatively affects transferrin saturation and iron status. The DICARIVA study

Assessing iron status: beyond serum ferritin and transferrin saturation.

The increasing prevalence of multiple comorbidities among anemic patients with chronic kidney disease has made the use of serum ferritin and transferrin saturation more challenging in diagnosing iron deficiency. Because serum ferritin is an acute-phase reactant and because the inflammatory state may inhibit the mobilization of iron from reticuloendothelial stores, the scenario of patients with ...

Indicators of the iron status of populations: free erythrocyte protoporphyrin and zinc protoporphyrin; serum and plasma iron, total iron binding capacity and transferrin saturation; and serum transferrin receptor

The plasma clearance and liver uptake of iron from transferrin of low and high iron saturation.

I. Serum labelled with radioactive iron was adjusted to different degrees of iron saturation and clearance of the tracer from the circulation of rats and its uptake by liver and intestine were followed. 2. The results showed that: (a) plasma iron clearance did not vary according to whether labelled iron was attached to transferrin at high or low iron saturation; (b) uptake of labelled iron by t...

Transferrin polymorphism influences iron status in blacks.

BACKGROUND Genetic variants of human transferrin (TF) have been described, but little is known about their functional differences. We studied iron status according to TF phenotype in a healthy Zimbabwean population and in subjects at risk of African iron overload. METHODS The study population consisted of 483 nondrinkers, 31 drinking spouse pairs, and 5 family pedigrees (n = 88) with index ca...

Transferrin saturation, plasma iron turnover, and transferrin uptake in normal humans.

The relationship between plasma iron, transferrin saturation, and plasma iron turnover was studied in 53 normal subjects whose transferrin saturation varied between 17% and 57%, in 25 normal subjects whose transferrin saturation was increased by iron infusion to between 67% and 100%, and in five subjects with early untreated idiopathic hemochromatosis whose transferrin saturation was continuall...